| 01/12 00:00 |  | [2]San Luis Quillot | [2]San Luis Quillot - Deportes La Sere[14] | 3-1 | Deportes La Sere[14] | 3-1 | |
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| 01/12 00:45 | | [1]Deportivo Cali | [1]Deportivo Cali - Deportiva Once C[4] | 1-0 | Deportiva Once C[4] | 1-1 | |
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| 01/12 01:00 | | [5]Municipal Iquiqu | [5]Municipal Iquiqu - Palestino[6] | 0-1 | Palestino[6] | 2-1 | |
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| 01/12 01:00 | | [8]Otago united | [8]Otago united - Canterbury Unite[6] | 0-3 | Canterbury Unite[6] | 1-4 | |
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| 01/12 02:00 | | [2]Necaxa(HON) | [2]Necaxa(HON) - Leones Negros Ud[5] | 1-1 | Leones Negros Ud[5] | 3-0 | |
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| 01/12 02:05 | | [3]Club Leon | [3]Club Leon - Monarcas Morelia[6] | 4-0 | Monarcas Morelia[6] | 2-1 | |
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| 01/12 03:00 | | [2]Kansas City Wiza | [2]Kansas City Wiza - Real Salt Lake[4] | | Real Salt Lake[4] | 1-0 | |
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| 01/12 04:00 | | Kamatamare Sanuk | Kamatamare Sanuk - Gainare Tottori | 1-1 | Gainare Tottori | 2-0 | |
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| 01/12 04:00 | | [9]Wellington Phoen | [9]Wellington Phoen - Western Sydney[2] | 0-0 | Western Sydney[2] | 1-1 | |
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| 01/12 05:00 | | Tokushima Vortis | Tokushima Vortis - JEF United Ichih | 1-1 | JEF United Ichih | 2-1 | |
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| 01/12 05:00 | | Kyoto Sanga | Kyoto Sanga - V-Varen Nagasaki | 0-0 | V-Varen Nagasaki | 2-1 | |
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| 01/12 05:00 | | [4]Jeonbuk Hyundai | [4]Jeonbuk Hyundai - FC Seoul[3] | 1-1 | FC Seoul[3] | 1-0 | |
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| 01/12 05:00 | | [1]Ulsan Hyundai Ho | [1]Ulsan Hyundai Ho - Pohang Steelers[2] | 0-1 | Pohang Steelers[2] | 2-1 | |
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| 01/12 05:00 | | [7]Incheon United | [7]Incheon United - Suwon Samsung Bl[5] | 2-1 | Suwon Samsung Bl[5] | 1-1 | |
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| 01/12 06:00 | | [10]Melbourne Heart | [10]Melbourne Heart - Adelaide United[8] | 3-3 | Adelaide United[8] | 2-2 | |
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| 01/12 09:50 | | [15]Terek Grozny | [15]Terek Grozny - Zenit St. Peters[1] | 1-1 | Zenit St. Peters[1] | 0-1 | |
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| 01/12 10:00 | | [2]BATE Borisov | [2]BATE Borisov - FC Gomel[6] | 2-0 | FC Gomel[6] | 2-1 | |
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| 01/12 10:00 | | [5]Shakhter Soligor | [5]Shakhter Soligor - Neman Grodno[3] | 1-1 | Neman Grodno[3] | 2-1 | |
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| 01/12 10:00 | | [4]FC Torpedo Zhodi | [4]FC Torpedo Zhodi - Dinamo Minsk[1] | 0-1 | Dinamo Minsk[1] | 1-1 | |
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| 01/12 10:00 | | [6]Banants | [6]Banants - Alashkert[8] | 7-0 | Alashkert[8] | 3-1 | |
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| 01/12 10:00 | | [1]Salgaocar Sports | [1]Salgaocar Sports - Sporting Clube d[5] | 0-1 | Sporting Clube d[5] | 1-0 | |
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| 01/12 11:00 | | [20]Real Betis | [20]Real Betis - Rayo Vallecano[19] | 2-2 | Rayo Vallecano[19] | 1-0 | |
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| 01/12 11:00 | | [6]FC Dacia Chisina | [6]FC Dacia Chisina - Sheriff Tiraspol[1] | 1-3 | Sheriff Tiraspol[1] | 1-1 | |
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| 01/12 11:00 | | [10]Real Murcia | [10]Real Murcia - Hercules FC[21] | 1-2 | Hercules FC[21] | 3-1 | |
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| 01/12 11:15 | | [5]Penafiel | [5]Penafiel - SC Covilha[7] | 0-2 | SC Covilha[7] | 2-1 | |
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| 01/12 11:30 | | [20]Catania | [20]Catania - AC Milan[13] | 1-3 | AC Milan[13] | 1-1 | |
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| 01/12 11:30 | | [8]Zorya | [8]Zorya - FC Dnipro Dnipro[4] | 3-0 | FC Dnipro Dnipro[4] | 1-1 | |
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| 01/12 11:30 | | [17]ADO Den Haag | [17]ADO Den Haag - Ajax[3] | 0-4 | Ajax[3] | 2-1 | |
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| 01/12 12:00 | | [9]Tottenham Hotspu | [9]Tottenham Hotspu - Manchester Unite[8] | 2-2 | Manchester Unite[8] | 1-1 | |
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| 01/12 12:00 | | [11]Kryliya Sovetov | [11]Kryliya Sovetov - FK Krasnodar[7] | 1-0 | FK Krasnodar[7] | 1-2 | |
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| 01/12 12:00 | | [10]Botosani | [10]Botosani - Concordia Chiajn[11] | 0-2 | Concordia Chiajn[11] | 1-1 | |
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| 01/12 12:00 | | [7]Ulisses FC | [7]Ulisses FC - Gandzasar Kapan[3] | 0-0 | Gandzasar Kapan[3] | 1-1 | |
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| 01/12 12:00 | | [10]Triglav Gorenjsk | [10]Triglav Gorenjsk - ND Gorica[4] | 1-5 | ND Gorica[4] | 1-1 | |
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| 01/12 12:00 | | [16]FK Rad Beograd | [16]FK Rad Beograd - Vozdovac[14] | 0-2 | Vozdovac[14] | 2-1 | |
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| 01/12 12:00 | | [1]FK Sutjeska Niks | [1]FK Sutjeska Niks - FK Buducnost Pod[5] | 1-1 | FK Buducnost Pod[5] | 1-2 | |
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| 01/12 12:00 | | [14]FK Mladost Velik | [14]FK Mladost Velik - Olimpik Sarajevo[6] | 1-0 | Olimpik Sarajevo[6] | 0-1 | |
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| 01/12 12:00 | | [9]FK Shkendija 79 | [9]FK Shkendija 79 - Pelister Bitola[3] | 0-0 | Pelister Bitola[3] | 1-2 | |
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| 01/12 12:00 | | [6]Metalurg Skopje | [6]Metalurg Skopje - FK Makedonija[10] | 1-0 | FK Makedonija[10] | 2-1 | |
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| 01/12 12:00 | | [8]Bregalnica Stip | [8]Bregalnica Stip - FK Gorno Lisice[7] | 1-1 | FK Gorno Lisice[7] | 1-0 | |
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| 01/12 12:00 | | [4]Horizont Turnovo | [4]Horizont Turnovo - Renova Cepciste[5] | 4-0 | Renova Cepciste[5] | 1-1 | |
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| 01/12 12:00 | | [8]Vllaznia Shkoder | [8]Vllaznia Shkoder - KS Kukesi[6] | 1-2 | KS Kukesi[6] | 2-1 | |
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| 01/12 12:00 | | [1]Skenderbeu Korca | [1]Skenderbeu Korca - Flamurtari[2] | 2-0 | Flamurtari[2] | 2-1 | |
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| 01/12 12:15 | | [11]Tadamon Sour | [11]Tadamon Sour - Al-Ansar(LIB)[5] | 1-1 | Al-Ansar(LIB)[5] | 1-1 | |
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| 01/12 12:30 | | [3]Greuther Furth | [3]Greuther Furth - Energie Cottbus[18] | 1-0 | Energie Cottbus[18] | 2-0 | |
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| 01/12 12:30 | | [12]SC Paderborn 07 | [12]SC Paderborn 07 - Erzgebirge Aue[13] | 1-1 | Erzgebirge Aue[13] | 2-1 | |
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| 01/12 12:30 | | [9]VfL Bochum | [9]VfL Bochum - TSV 1860 Munchen[10] | 1-2 | TSV 1860 Munchen[10] | 1-1 | |
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| 01/12 12:30 | | [12]Marienlyst | [12]Marienlyst - Silkeborg[3] | 1-3 | Silkeborg[3] | 1-2 | |
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| 01/12 12:30 | | [3]Pune FC | [3]Pune FC - Prayag United SC[4] | 1-1 | Prayag United SC[4] | 1-0 | |
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| 01/12 12:30 | | [9]Panahaiki-2005 | [9]Panahaiki-2005 - AO Episkopis Ret[6] | 0-1 | AO Episkopis Ret[6] | 1-1 | |
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| 01/12 12:45 | | [5]St. Gallen | [5]St. Gallen - FC Zurich[7] | 2-1 | FC Zurich[7] | 2-1 | |
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| 01/12 12:45 | | [10]Lausanne Sports | [10]Lausanne Sports - Thun[6] | 0-2 | Thun[6] | 1-1 | |
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| 01/12 12:45 | | Partick Thistle | Partick Thistle - Aberdeen | 0-1 | Aberdeen | 0-2 | |
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| 01/12 13:00 | | [13]Bordeaux | [13]Bordeaux - Ajaccio[19] | 4-0 | Ajaccio[19] | 1-0 | |
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| 01/12 13:00 | | [10]Nordsjaelland | [10]Nordsjaelland - Randers FC[9] | 1-1 | Randers FC[9] | 1-0 | |
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| 01/12 13:00 | | [18]Chemnitzer | [18]Chemnitzer - SV Elversberg[10] | 2-0 | SV Elversberg[10] | 2-1 | |
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| 01/12 13:00 | | [10]Newport IW | [10]Newport IW - Chesterfield[2] | 3-2 | Chesterfield[2] | 2-1 | |
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| 01/12 13:00 | | [17]Aris Thessalonik | [17]Aris Thessalonik - Panthrakikos[12] | 2-2 | Panthrakikos[12] | 1-1 | |
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| 01/12 13:00 | | [1]Olympiakos Volou | [1]Olympiakos Volou - Fostiras[11] | 5-1 | Fostiras[11] | 2-0 | |
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| 01/12 13:00 | | [12]Aharnaikos | [12]Aharnaikos - Fokikos[7] | 1-0 | Fokikos[7] | 1-1 | |
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| 01/12 13:00 | | [14]Vizas Megaron | [14]Vizas Megaron - Chania FC[3] | 0-2 | Chania FC[3] | 1-1 | |
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| 01/12 13:00 | | [6]Aiginiakos FC | [6]Aiginiakos FC - Anagenisi Kardit[4] | 1-1 | Anagenisi Kardit[4] | 2-1 | |
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| 01/12 13:00 | | [11]Anagennisi Giann | [11]Anagennisi Giann - Vataniakos[14] | 0-1 | Vataniakos[14] | 1-0 | |
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| 01/12 13:00 | | [10]Pierikos | [10]Pierikos - Niki Volou[2] | 2-1 | Niki Volou[2] | 1-1 | |
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| 01/12 13:00 | | [1]Kerkyra | [1]Kerkyra - Zakynthos[5] | 1-0 | Zakynthos[5] | 2-0 | |
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| 01/12 13:00 | | [8]Tyrnavos 2005 | [8]Tyrnavos 2005 - AO Kavala[13] | 4-2 | AO Kavala[13] | 2-1 | |
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| 01/12 13:00 | | [16]Sassari Torres | [16]Sassari Torres - Monza[8] | 1-1 | Monza[8] | 2-1 | |
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| 01/12 13:30 | | [11]Lierse | [11]Lierse - Standard Liege[1] | 0-5 | Standard Liege[1] | 1-1 | |
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| 01/12 13:30 | | [2]Maribor | [2]Maribor - Zavrc[3] | 3-4 | Zavrc[3] | 3-2 | |
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| 01/12 13:30 | | [8]Feyenoord | [8]Feyenoord - PSV Eindhoven[10] | 3-1 | PSV Eindhoven[10] | 2-1 | |
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| 01/12 13:30 | | [2]Vitesse Arnhem | [2]Vitesse Arnhem - Cambuur Leeuwaar[14] | 3-0 | Cambuur Leeuwaar[14] | 2-1 | |
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| 01/12 13:30 | | [9]Volendam | [9]Volendam - Dordrecht[1] | 2-2 | Dordrecht[1] | 1-2 | |
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| 01/12 13:30 | | [2]Mamelodi Sundown | [2]Mamelodi Sundown - Moroka Swallows[4] | 2-1 | Moroka Swallows[4] | 2-1 | |
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| 01/12 13:30 | | [14]Olympique de Bej | [14]Olympique de Bej - E.Gawafel.S.Gafs[8] | 1-2 | E.Gawafel.S.Gafs[8] | 1-0 | |
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| 01/12 13:30 | | [9]J.S. Kairouanais | [9]J.S. Kairouanais - A.S.Marsa[4] | 0-0 | A.S.Marsa[4] | 2-1 | |
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| 01/12 13:30 | | [15]Grombalia | [15]Grombalia - CS.Hammam-Lif[12] | 2-1 | CS.Hammam-Lif[12] | 1-0 | |
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| 01/12 13:30 | | [13]Stade tunisien | [13]Stade tunisien - ES du Sahel[3] | 1-0 | ES du Sahel[3] | 1-1 | |
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| 01/12 13:30 | | [10]La Palme de Toze | [10]La Palme de Toze - Stade Gabesien[5] | 2-0 | Stade Gabesien[5] | 2-1 | |
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| 01/12 13:30 | | [11]Etoile Metlaoui | [11]Etoile Metlaoui - C.A.Bizertin[6] | 2-2 | C.A.Bizertin[6] | 1-0 | |
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| 01/12 13:30 | | [7]Como | [7]Como - Venezia[5] | 2-0 | Venezia[5] | 1-0 | |
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| 01/12 13:30 | | [6]Cremonese | [6]Cremonese - Carrarese[13] | 2-2 | Carrarese[13] | 2-1 | |
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| 01/12 13:30 | | [14]Pro Patria | [14]Pro Patria - ACD Virtus Entel[1] | 1-1 | ACD Virtus Entel[1] | 0-1 | |
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| 01/12 13:30 | | [2]Pro Vercelli | [2]Pro Vercelli - Vicenza[3] | 1-1 | Vicenza[3] | 1-0 | |
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| 01/12 13:30 | | [12]Reggiana | [12]Reggiana - Lumezzane[9] | 2-2 | Lumezzane[9] | 2-2 | |
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| 01/12 13:30 | | [15]San Marino Calci | [15]San Marino Calci - Feralpisalo[11] | 0-3 | Feralpisalo[11] | 3-3 | |
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| 01/12 13:30 | | [4]Savona | [4]Savona - SudTirol[10] | 3-1 | SudTirol[10] | 3-1 | |
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| 01/12 13:30 | | [13]Roses United | [13]Roses United - Vasco da Gama(RS[5] | 0-1 | Vasco da Gama(RS[5] | 1-1 | |
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| 01/12 13:30 | | [6]United FC (RSA) | [6]United FC (RSA) - Black Leopards[10] | 0-1 | Black Leopards[10] | 3-0 | |
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| 01/12 13:30 | | [12]African Warriors | [12]African Warriors - Blackburn Rovers[14] | 3-2 | Blackburn Rovers[14] | 2-1 | |
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| 01/12 13:30 | | [13]Ascoli | [13]Ascoli - Prato[7] | 1-1 | Prato[7] | 1-2 | |
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| 01/12 13:30 | | [10]Lecce | [10]Lecce - Grosseto[12] | 1-0 | Grosseto[12] | 1-1 | |
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| 01/12 13:30 | | [3]Pisa | [3]Pisa - Salernitana[9] | 0-0 | Salernitana[9] | 2-1 | |
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| 01/12 13:30 | | [14]Esperia Viareggi | [14]Esperia Viareggi - Perugia[4] | 0-2 | Perugia[4] | 1-1 | |
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| 01/12 13:30 | | [12]Alessandria | [12]Alessandria - Virtus Verona[5] | 3-1 | Virtus Verona[5] | 1-1 | |
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| 01/12 13:30 | | [17]Castiglione | [17]Castiglione - Bassano[2] | 0-1 | Bassano[2] | 1-2 | |
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| 01/12 13:30 | | [11]Cuneo | [11]Cuneo - Mantova[9] | 1-1 | Mantova[9] | 2-1 | |
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| 01/12 13:30 | | [13]Forli | [13]Forli - Rimini[3] | 1-0 | Rimini[3] | 1-2 | |
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| 01/12 13:30 | | [4]Real Vicenza | [4]Real Vicenza - Bellaria Igea Ma[14] | 2-1 | Bellaria Igea Ma[14] | 3-0 | |
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| 01/12 13:30 | | [6]Renate AC | [6]Renate AC - Delta Porto Toll[15] | 0-2 | Delta Porto Toll[15] | 1-1 | |
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| 01/12 13:30 | | [10]Spal | [10]Spal - Pergolettese[7] | 2-1 | Pergolettese[7] | 2-1 | |
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| 01/12 13:30 | | [1]Santarcangelo | [1]Santarcangelo - ASD Bra[18] | 3-0 | ASD Bra[18] | 2-0 | |
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| 01/12 13:30 | | [18]Arzanese | [18]Arzanese - Teramo[2] | 1-0 | Teramo[2] | 1-2 | |
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| 01/12 13:30 | | [12]Chieti | [12]Chieti - Gavorrano[17] | 2-0 | Gavorrano[17] | 1-0 | |
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| 01/12 13:30 | | [14]Messina | [14]Messina - Vigor Lamezia[7] | 1-4 | Vigor Lamezia[7] | 1-1 | |
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| 01/12 13:30 | | [1]Cosenza Calcio 1 | [1]Cosenza Calcio 1 - Ischia Isolaverd[8] | 1-1 | Ischia Isolaverd[8] | 1-0 | |
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| 01/12 13:30 | | [10]Poggibonsi | [10]Poggibonsi - Foggia[3] | 0-1 | Foggia[3] | 1-0 | |
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| 01/12 13:30 | | [4]Tuttocuoio | [4]Tuttocuoio - AS Sorrento Calc[16] | 0-2 | AS Sorrento Calc[16] | 1-0 | |
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| 01/12 13:30 | | [6]Trabzonspor | [6]Trabzonspor - Kayseri Erciyesp[16] | 3-1 | Kayseri Erciyesp[16] | 1-0 | |
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| 01/12 13:30 | | [6]Al-Nejmeh | [6]Al-Nejmeh - Shabab Sahel[4] | 1-1 | Shabab Sahel[4] | 1-1 | |
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| 01/12 13:30 | | [2]A.S Djerba | [2]A.S Djerba - C Hilalien[9] | 0-0 | C Hilalien[9] | 1-0 | |
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| 01/12 13:30 | | [1]AS Gabes | [1]AS Gabes - Sporting Ben Aro[5] | 2-0 | Sporting Ben Aro[5] | 1-0 | |
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| 01/12 13:30 | | [6]AS Kasserine | [6]AS Kasserine - Croissant Msaken[7] | 1-1 | Croissant Msaken[7] | 2-1 | |
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| 01/12 13:30 | | [4]CO Sidi Bouzid | [4]CO Sidi Bouzid - E.S.Beni Khalled[8] | 1-0 | E.S.Beni Khalled[8] | 2-0 | |
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| 01/12 13:30 | | [5]Sfax Railways | [5]Sfax Railways - ES Hamam-Sousse[1] | 2-1 | ES Hamam-Sousse[1] | 1-0 | |
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| 01/12 13:30 | | [3]Jendouba Sport | [3]Jendouba Sport - US Ben Guerdane[2] | 0-0 | US Ben Guerdane[2] | 2-2 | |
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| 01/12 13:30 | | [10]Olympique du Kef | [10]Olympique du Kef - Enfidha Sport[6] | 2-0 | Enfidha Sport[6] | 1-1 | |
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| 01/12 14:00 | | [11]Atalanta | [11]Atalanta - AS Roma[2] | 1-1 | AS Roma[2] | 0-1 | |
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| 01/12 14:00 | | [14]Cagliari | [14]Cagliari - Sassuolo[15] | 2-2 | Sassuolo[15] | 1-1 | |
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| 01/12 14:00 | | [4]Inter Milan | [4]Inter Milan - Sampdoria[18] | 1-1 | Sampdoria[18] | 3-2 | |
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| 01/12 14:00 | | [19]Chievo | [19]Chievo - Livorno[16] | 3-0 | Livorno[16] | 2-1 | |
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| 01/12 14:00 | | [1]Dinamo Zagreb | [1]Dinamo Zagreb - Hajduk Split[2] | 2-2 | Hajduk Split[2] | 2-1 | |
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| 01/12 14:00 | | [6]Mlada Boleslav | [6]Mlada Boleslav - Banik Ostrava[13] | 4-0 | Banik Ostrava[13] | 2-1 | |
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| 01/12 14:00 | | [9]Eendracht Aalst | [9]Eendracht Aalst - Royal Antwerp[5] | 1-0 | Royal Antwerp[5] | 1-1 | |
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| 01/12 14:00 | | [18]CS Wezet | [18]CS Wezet - Sint Truiden[4] | 1-0 | Sint Truiden[4] | 0-2 | |
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| 01/12 14:00 | | [9]Aversa Normanna | [9]Aversa Normanna - MartinaFranca[15] | 0-0 | MartinaFranca[15] | 2-0 | |
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| 01/12 14:05 | | [13]Hull City | [13]Hull City - Liverpool[2] | 3-1 | Liverpool[2] | 1-0 | |
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| 01/12 14:30 | | [14]Hannover 96 | [14]Hannover 96 - Eintracht Frankf[15] | 2-0 | Eintracht Frankf[15] | 2-2 | |
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| 01/12 14:30 | | [3]Spartak Moscow | [3]Spartak Moscow - Volga Nizhny Nov[12] | 6-1 | Volga Nizhny Nov[12] | 3-0 | |
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| 01/12 14:30 | | [9]Ruch Chorzow | [9]Ruch Chorzow - Cracovia Krakow[8] | 3-2 | Cracovia Krakow[8] | 0-1 | |
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| 01/12 14:30 | | [2]Itihad Z. Khemis | [2]Itihad Z. Khemis - Raja de Beni Mel[1] | 0-0 | Raja de Beni Mel[1] | 1-0 | |
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| 01/12 14:30 | | [16]USM Oujda | [16]USM Oujda - JSM Jeunesse Spo[13] | 1-1 | JSM Jeunesse Spo[13] | 1-0 | |
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| 01/12 14:30 | | [5]CAYB Club Athlet | [5]CAYB Club Athlet - USM US Mohammedi[8] | 0-1 | USM US Mohammedi[8] | 1-0 | |
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| 01/12 14:30 | | [14]Union Sportive A | [14]Union Sportive A - Racing Casablanc[11] | 1-0 | Racing Casablanc[11] | 1-1 | |
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| 01/12 14:30 | | [7]JSK Chabab Kasba | [7]JSK Chabab Kasba - MCO Mouloudia Ou[10] | 0-0 | MCO Mouloudia Ou[10] | 0-0 | |
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| 01/12 15:00 | | [4]Young Boys | [4]Young Boys - Basel[1] | 2-2 | Basel[1] | 1-2 | |
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| 01/12 15:00 | | [13]Volyn | [13]Volyn - Metalurh Zaporiz[15] | 2-0 | Metalurh Zaporiz[15] | 2-1 | |
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| 01/12 15:00 | | [6]Lugano | [6]Lugano - Vaduz[1] | 0-0 | Vaduz[1] | 0-2 | |
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| 01/12 15:00 | | [4]Servette | [4]Servette - Wohlen[10] | 1-0 | Wohlen[10] | 3-1 | |
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| 01/12 15:00 | | [14]Wigan Athletic | [14]Wigan Athletic - Derby County[8] | 1-3 | Derby County[8] | 1-2 | |
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| 01/12 15:00 | | [15]Oldham Athletic | [15]Oldham Athletic - Bradford City[9] | 1-1 | Bradford City[9] | 1-1 | |
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| 01/12 15:00 | | [13]Wrexham | [13]Wrexham - Tamworth[21] | | Tamworth[21] | 3-0 | |
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| 01/12 15:00 | | [2]Univ Catolica | [2]Univ Catolica - Colo Colo[11] | 1-0 | Colo Colo[11] | 3-1 | |
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| 01/12 15:00 | | [1]Portimonense | [1]Portimonense - CF Uniao Madeira[13] | 2-1 | CF Uniao Madeira[13] | 2-1 | |
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| 01/12 15:00 | | [22]Clube Desportivo | [22]Clube Desportivo - Feirense[21] | 0-1 | Feirense[21] | 1-0 | |
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| 01/12 15:00 | | [9]Aves | [9]Aves - GD Chaves[14] | 0-2 | GD Chaves[14] | 1-0 | |
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| 01/12 15:00 | | [11]Leixoes | [11]Leixoes - Viseu[17] | 0-0 | Viseu[17] | 1-0 | |
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| 01/12 15:00 | | [18]Atletico Clube P | [18]Atletico Clube P - SC Farense[12] | 0-2 | SC Farense[12] | 0-0 | |
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| 01/12 15:00 | | [15]Beira Mar | [15]Beira Mar - Oliveirense[19] | 1-0 | Oliveirense[19] | 1-0 | |
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| 01/12 15:00 | | [10]SL Benfica B | [10]SL Benfica B - Porto B[4] | 3-1 | Porto B[4] | 2-1 | |
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| 01/12 15:00 | | [8]KAC de Kenitra | [8]KAC de Kenitra - Wydad Fes[16] | 1-0 | Wydad Fes[16] | 1-0 | |
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| 01/12 15:00 | | [3]Kawkab de Marrak | [3]Kawkab de Marrak - OCK Olympique de[9] | 0-0 | OCK Olympique de[9] | 1-0 | |
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| 01/12 15:00 | | Hearts | Hearts - Celtic FC | 0-7 | Celtic FC | 1-2 | |
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| 01/12 15:00 | | [13]E.N.Paralimniou | [13]E.N.Paralimniou - Doxa Katokopias[7] | 1-0 | Doxa Katokopias[7] | 1-4 | |
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| 01/12 15:00 | | [4]AEL Limassol | [4]AEL Limassol - Alki[14] | 3-0 | Alki[14] | 3-0 | |
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| 01/12 15:15 | | [6]NK Olimpija Ljub | [6]NK Olimpija Ljub - Rudar Velenje[5] | 0-3 | Rudar Velenje[5] | 1-1 | |
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| 01/12 15:15 | | [11]Panionios | [11]Panionios - SKODA Xanthi[10] | 0-0 | SKODA Xanthi[10] | 2-1 | |
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| 01/12 15:15 | | [18]Veria FC | [18]Veria FC - Levadiakos[13] | 4-3 | Levadiakos[13] | 2-1 | |
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| 01/12 15:15 | | [15]OFI Crete | [15]OFI Crete - Kalloni[6] | 3-1 | Kalloni[6] | 1-1 | |
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| 01/12 15:30 | | [3]Diosgyor VTK | [3]Diosgyor VTK - Gyori ETO[5] | 1-2 | Gyori ETO[5] | 2-1 | |
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| 01/12 15:30 | | [1]Red Bull Salzbur | [1]Red Bull Salzbur - SV Ried[5] | 4-0 | SV Ried[5] | 3-1 | |
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| 01/12 15:30 | | [18]NEC Nijmegen | [18]NEC Nijmegen - AZ Alkmaar[4] | 3-2 | AZ Alkmaar[4] | 1-2 | |
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| 01/12 15:59 | | [9]Bastia | [9]Bastia - Evian Thonon Gai[16] | 2-0 | Evian Thonon Gai[16] | 2-0 | |
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| 01/12 15:59 | | [12]Granada CF | [12]Granada CF - Sevilla[8] | 1-2 | Sevilla[8] | 1-1 | |
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| 01/12 15:59 | | [8]Odense BK | [8]Odense BK - AGF Aarhus[5] | 4-1 | AGF Aarhus[5] | 1-3 | |
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| 01/12 15:59 | | [15]Bohemians 1905 | [15]Bohemians 1905 - Brno[14] | 1-1 | Brno[14] | 1-1 | |
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| 01/12 15:59 | | [6]Nacional da Made | [6]Nacional da Made - Vitoria Setubal[11] | 2-2 | Vitoria Setubal[11] | 2-1 | |
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| 01/12 15:59 | | [16]FC Arouca | [16]FC Arouca - Maritimo[12] | 1-2 | Maritimo[12] | 2-1 | |
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| 01/12 15:59 | | [13]Belenenses | [13]Belenenses - Gil Vicente[5] | 0-0 | Gil Vicente[5] | 2-1 | |
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| 01/12 15:59 | | [20]Santa Clara | [20]Santa Clara - CD Tondela[6] | 0-1 | CD Tondela[6] | 1-1 | |
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| 01/12 15:59 | | [19]Alaves | [19]Alaves - Ponferradina[14] | 2-2 | Ponferradina[14] | 2-1 | |
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| 01/12 15:59 | | [16]Girona | [16]Girona - Tenerife[17] | 2-2 | Tenerife[17] | 1-1 | |
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| 01/12 15:59 | | [20]Sabadell | [20]Sabadell - Mirandes[12] | 3-1 | Mirandes[12] | 2-1 | |
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| 01/12 15:59 | | [6]Sporting Gijon | [6]Sporting Gijon - AD Alcorcon[15] | 2-2 | AD Alcorcon[15] | 1-1 | |
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| 01/12 15:59 | | [7]Apollon Kalamari | [7]Apollon Kalamari - Iraklis[9] | 0-1 | Iraklis[9] | 1-0 | |
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| 01/12 15:59 | | [10]Ethnikos Achnas | [10]Ethnikos Achnas - Omonia Nicosia F[5] | 1-2 | Omonia Nicosia F[5] | 1-3 | |
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| 01/12 16:10 | | [3]Chelsea | [3]Chelsea - Southampton[7] | 3-1 | Southampton[7] | 2-1 | |
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| 01/12 16:10 | | [6]Manchester City | [6]Manchester City - Swansea City[11] | 3-0 | Swansea City[11] | 3-1 | |
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| 01/12 16:30 | | [4]Borussia Monchen | [4]Borussia Monchen - SC Freiburg[16] | 1-0 | SC Freiburg[16] | 2-1 | |
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| 01/12 16:30 | | [18]ASC Corona Braso | [18]ASC Corona Braso - Pandurii Targu-J[4] | 1-1 | Pandurii Targu-J[4] | 1-2 | |
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| 01/12 16:30 | | [4]CD El Nacional | [4]CD El Nacional - Macara[12] | 2-0 | Macara[12] | 1-0 | |
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| 01/12 16:30 | | [9]LDU Quito | [9]LDU Quito - Deportivo Cuenca[10] | 2-1 | Deportivo Cuenca[10] | 2-1 | |
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| 01/12 17:00 | | [16]Podbeskidzie Bie | [16]Podbeskidzie Bie - Legia Warszawa[1] | 1-0 | Legia Warszawa[1] | 1-0 | |
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| 01/12 17:00 | | [5]Anderlecht | [5]Anderlecht - Cercle Brugge[9] | 2-1 | Cercle Brugge[9] | 2-1 | |
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| 01/12 17:00 | | [7]Eskisehirspor | [7]Eskisehirspor - Kardemir Karabuk[11] | 0-0 | Kardemir Karabuk[11] | 2-0 | |
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| 01/12 17:00 | | [2]Kasimpasa | [2]Kasimpasa - Galatasaray[4] | 1-1 | Galatasaray[4] | 2-1 | |
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| 01/12 17:15 | | [13]Real Jaen CF | [13]Real Jaen CF - Real M. B[22] | 0-1 | Real M. B[22] | 2-0 | |
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| 01/12 17:20 | | [3]Deportivo Sapris | [3]Deportivo Sapris - Alajuelense[2] | 1-0 | Alajuelense[2] | 2-1 | |
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| 01/12 17:30 | | [1]Juventus | [1]Juventus - Udinese[12] | 1-0 | Udinese[12] | 3-1 | |
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| 01/12 17:30 | | [4]Haladas | [4]Haladas - Videoton[2] | 1-1 | Videoton[2] | 1-2 | |
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| 01/12 17:30 | | [1]Olympiakos | [1]Olympiakos - Ergotelis[7] | 3-0 | Ergotelis[7] | 2-1 | |
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| 01/12 17:45 | | [10]Rio Ave | [10]Rio Ave - Benfica[3] | 1-3 | Benfica[3] | 1-1 | |
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| 01/12 18:00 | | [10]Valencia | [10]Valencia - Osasuna[16] | 3-0 | Osasuna[16] | 2-1 | |
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| 01/12 18:00 | | [4]Brondby IF | [4]Brondby IF - FC Copenhagen[3] | 1-3 | FC Copenhagen[3] | 2-1 | |
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| 01/12 18:00 | | [4]Rijeka | [4]Rijeka - Belupo[8] | 2-2 | Belupo[8] | 1-1 | |
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| 01/12 18:00 | | [2]FC Viktoria Plze | [2]FC Viktoria Plze - Marila Pribram[12] | 2-0 | Marila Pribram[12] | 3-0 | |
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| 01/12 18:00 | | [3]Rapid Wien | [3]Rapid Wien - FC Wacker Innsbr[10] | 3-0 | FC Wacker Innsbr[10] | 3-1 | |
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| 01/12 18:00 | | [4]Universidad de S | [4]Universidad de S - Marquense[5] | 1-0 | Marquense[5] | 1-1 | |
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| 01/12 18:30 | | [8]Manta FC | [8]Manta FC - Club Sport Emele[1] | 0-0 | Club Sport Emele[1] | 1-1 | |
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| 01/12 18:30 | | [14]Maghreb Fez | [14]Maghreb Fez - Maghrib Associat[2] | 1-1 | Maghrib Associat[2] | 0-1 | |
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| 01/12 18:30 | | [7]D. Concepcion | [7]D. Concepcion - Barnechea[1] | 0-2 | Barnechea[1] | 1-2 | |
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| 01/12 19:00 | | [2]Steaua Bucuresti | [2]Steaua Bucuresti - Petrolul Ploiest[3] | 1-1 | Petrolul Ploiest[3] | 2-1 | |
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| 01/12 19:00 | | [3]Heredia | [3]Heredia - Halcones[6] | 4-0 | Halcones[6] | 3-1 | |
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| 01/12 19:00 | | [16]Coritiba (PR) | [16]Coritiba (PR) - Botafogo RJ[5] | 2-1 | Botafogo RJ[5] | 2-1 | |
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| 01/12 19:00 | | [15]Criciuma EC | [15]Criciuma EC - Sao Paulo[9] | 1-0 | Sao Paulo[9] | 1-2 | |
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| 01/12 19:00 | | [1]Cruzeiro | [1]Cruzeiro - Bahia(BA)[13] | 1-2 | Bahia(BA)[13] | 3-0 | |
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| 01/12 19:00 | | [19]Ponte Preta | [19]Ponte Preta - Portuguesa Despo[14] | 0-2 | Portuguesa Despo[14] | 2-1 | |
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| 01/12 19:00 | | [18]Vasco da Gama | [18]Vasco da Gama - Nautico Capibari[20] | 2-0 | Nautico Capibari[20] | 4-1 | |
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| 01/12 19:00 | | [7]Vitoria BA | [7]Vitoria BA - Flamengo[11] | 4-2 | Flamengo[11] | 1-1 | |
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| 01/12 19:00 | | [10]Santiago Morning | [10]Santiago Morning - Temuco[12] | 4-0 | Temuco[12] | 2-0 | |
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| 01/12 19:30 | | [4]Racing Genk | [4]Racing Genk - Oud Heverlee[13] | 3-0 | Oud Heverlee[13] | 2-0 | |
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| 01/12 19:30 | | [7]Kortrijk | [7]Kortrijk - Zulte-Waregem[3] | 1-1 | Zulte-Waregem[3] | 3-1 | |
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| 01/12 19:30 | | [14]Atletico El Vigi | [14]Atletico El Vigi - Llaneros de Guan[16] | 1-2 | Llaneros de Guan[16] | 2-1 | |
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| 01/12 19:45 | | [7]Liga de Loja | [7]Liga de Loja - Independiente Jo[2] | 2-1 | Independiente Jo[2] | 2-1 | |
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| 01/12 19:45 | | [2]Sporting Lisbon | [2]Sporting Lisbon - Pacos de Ferreir[15] | 4-0 | Pacos de Ferreir[15] | 3-1 | |
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| 01/12 20:00 | | [1]Paris Saint Germ | [1]Paris Saint Germ - Lyon[8] | 4-0 | Lyon[8] | 3-0 | |
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| 01/12 20:00 | | [5]Athletic Bilbao | [5]Athletic Bilbao - Barcelona[1] | 1-0 | Barcelona[1] | 0-1 | |
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| 01/12 20:00 | | [15]Deportivo Petare | [15]Deportivo Petare - La Guaira[17] | 1-1 | La Guaira[17] | 0-0 | |
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| 01/12 20:00 | | [14]Gimnasia La Plat | [14]Gimnasia La Plat - Quilmes[16] | 3-2 | Quilmes[16] | 2-1 | |
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| 01/12 20:00 | | [4]Garcilaso | [4]Garcilaso - Pacifico FC Buen[8] | 3-0 | Pacifico FC Buen[8] | 3-0 | |
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| 01/12 20:00 | | [5]Deportivo Union | [5]Deportivo Union - Sport Huancayo[7] | 2-0 | Sport Huancayo[7] | 1-1 | |
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| 01/12 20:00 | | [2]Sporting Cristal | [2]Sporting Cristal - FBC Melgar[6] | 4-1 | FBC Melgar[6] | 1-0 | |
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| 01/12 20:00 | | [7]Jose Galvez Chim | [7]Jose Galvez Chim - Universitario De[2] | 2-2 | Universitario De[2] | 2-1 | |
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| 01/12 20:00 | | [2]CA River Plate | [2]CA River Plate - El Tanque Sisley[5] | 1-1 | El Tanque Sisley[5] | 1-1 | |
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| 01/12 20:00 | | [1]Danubio FC | [1]Danubio FC - Rentistas[7] | 0-3 | Rentistas[7] | 2-1 | |
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| 01/12 20:00 | | [13]Cerro Largo | [13]Cerro Largo - Centro Atletico [16] | 0-1 | Centro Atletico [16] | 1-1 | |
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| 01/12 20:00 | | [3]Nacional Montevi | [3]Nacional Montevi - Cerro Montevideo[12] | 1-0 | Cerro Montevideo[12] | 2-1 | |
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| 01/12 20:00 | | [8]Numancia | [8]Numancia - Recreativo Huelv[2] | 2-3 | Recreativo Huelv[2] | 2-1 | |
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| 01/12 20:00 | | [9]Club Guabira | [9]Club Guabira - The Strongest[3] | 3-5 | The Strongest[3] | 1-1 | |
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| 01/12 20:00 | | [6]Universitario de | [6]Universitario de - San Jose[2] | 1-1 | San Jose[2] | 3-1 | |
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| 01/12 20:00 | | [1]Bolivar | [1]Bolivar - Aurora[12] | 4-0 | Aurora[12] | 4-1 | |
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| 01/12 20:00 | | [8]Union San Felipe | [8]Union San Felipe - CD Copiapo S.A.[5] | 0-1 | CD Copiapo S.A.[5] | 2-0 | |
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| 01/12 20:00 | | [9]San Marcos de Ar | [9]San Marcos de Ar - CD Magallanes[4] | 0-0 | CD Magallanes[4] | 2-1 | |
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| 01/12 20:00 | | [13]Lota Schwager | [13]Lota Schwager - Curico Unido[11] | 1-3 | Curico Unido[11] | 1-1 | |
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| 01/12 20:15 | | [3]Independiente Sa | [3]Independiente Sa - Deportivo Itagui[4] | 0-2 | Deportivo Itagui[4] | 2-1 | |
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| 01/12 20:30 | | [18]Yaracuyanos | [18]Yaracuyanos - Aragua FC[10] | 1-1 | Aragua FC[10] | 1-1 | |
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| 01/12 20:30 | | [6]Deportivo Tachir | [6]Deportivo Tachir - Zulia FC[12] | 2-0 | Zulia FC[12] | 3-1 | |
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| 01/12 20:30 | | [5]Zamora Barinas | [5]Zamora Barinas - Caracas FC[1] | 2-1 | Caracas FC[1] | 0-1 | |
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| 01/12 20:30 | | [3]Deportivo Anzoat | [3]Deportivo Anzoat - Carabobo FC[4] | 2-1 | Carabobo FC[4] | 2-1 | |
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| 01/12 20:30 | | [7]Atletico Venezue | [7]Atletico Venezue - Trujillanos[9] | 2-2 | Trujillanos[9] | 1-1 | |
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| 01/12 20:30 | | [11]Tucanes Amazonas | [11]Tucanes Amazonas - Mineros de Guaya[2] | 2-3 | Mineros de Guaya[2] | 1-0 | |
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| 01/12 20:30 | | [1]San Lorenzo | [1]San Lorenzo - Estudiantes La P[7] | 0-0 | Estudiantes La P[7] | 1-1 | |
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| 01/12 21:00 | | [11]Deportivo Queved | [11]Deportivo Queved - Sociedad Deporti[5] | 2-0 | Sociedad Deporti[5] | 1-0 | |
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| 01/12 21:00 | | [3]Crucero del Nort | [3]Crucero del Nort - Atletico Tucuman[7] | 1-1 | Atletico Tucuman[7] | 1-0 | |
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| 01/12 21:15 | | [4]Lanus | [4]Lanus - Boca Juniors[6] | 2-2 | Boca Juniors[6] | 1-0 | |
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| 01/12 21:30 | | [3]Gremio RS | [3]Gremio RS - Goias[4] | 1-0 | Goias[4] | 2-1 | |
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| 01/12 21:30 | | [8]Santos | [8]Santos - Atletico Paranae[2] | 2-1 | Atletico Paranae[2] | 1-0 | |
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| 01/12 21:30 | | [9]Nublense | [9]Nublense - Everton CD[14] | 1-0 | Everton CD[14] | 2-1 | |
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| 01/12 21:45 | | [6]Barcelona SC(ECU | [6]Barcelona SC(ECU - Universidad Cato[3] | 0-1 | Universidad Cato[3] | 2-1 | |
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| 01/12 22:00 | | [4]Cartagines Depor | [4]Cartagines Depor - Herediano[1] | 0-2 | Herediano[1] | 1-2 | |
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| 01/12 22:00 | | [16]Orlando Pirates | [16]Orlando Pirates - Supersport Unite[2] | | Supersport Unite[2] | 1-0 | |
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| 01/12 22:00 | | [14]San Martin San J | [14]San Martin San J - CA Brown Adrogue[10] | 3-1 | CA Brown Adrogue[10] | 2-1 | |
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| 01/12 22:30 | | [7]Oriente Petroler | [7]Oriente Petroler - Nacional Potosi[5] | 0-0 | Nacional Potosi[5] | 1-1 | |
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| 01/12 22:30 | | [2]Real Espana | [2]Real Espana - CD Olimpia[3] | 1-1 | CD Olimpia[3] | 1-1 | |
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| 01/12 23:00 | | [1]Club America | [1]Club America - Tigres UANL[8] | 1-1 | Tigres UANL[8] | 1-1 | |
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| 01/12 23:00 | | [8]Sportivo Belgran | [8]Sportivo Belgran - Aldosivi Mar del[21] | 0-0 | Aldosivi Mar del[21] | 1-0 | |
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| 01/12 23:00 | | [20]Sarmiento Junin | [20]Sarmiento Junin - Villa San Carlos[22] | 1-0 | Villa San Carlos[22] | 1-1 | |
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